HEAL Funding Opportunities | National Institutes of Health (NIH)

Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock () or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites. Breadcrumb HEAL Funding Opportunities HEAL Funding Opportunities The NIH HEAL Initiative invests in research to accelerate scientific solutions to address the national opioid overdose crisis and improve pain management. Below, you can explore open Funding Opportunities and Forecasts that support innovative research across the HEAL portfolio. Opportunity or Forecast ID Title Activity Code Research Area Closing Date PAR-25-154 HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) R03 Preclinical 7/16/2026 PAR-25-051 Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) UG3/UH3 Preclinical 8/18/2026 RFA-AT-25-003 HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional) R15 Preclinical 11/23/2026 RFA-NS-25-023 HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) R61/R33 Preclinical 1/15/2027 PA-24-185 Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) K23 Workforce Development 5/7/2027 PA-24-194 NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) K99/R00 Workforce Development 5/7/2027 PA-24-176 Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) K01 Workforce Development 5/7/2027 PAR-25-100 Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional) R34 Implementation & Health Services, Recovery Services 5/8/2027 PAS-25-236 D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional) R03 Data Dissemination & Secondary Analysis 9/7/2027 RFA-DA-26-055 Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed) R01 Data Dissemination & Secondary Analysis 12/3/2027 RFA-DA-26-056 Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed) R21 Data Dissemination & Secondary Analysis 12/3/2027 PA-25-302 NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) R03 Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis 1/7/2028 PA-25-304 NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) R21 Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis 1/7/2028 PA-25-301 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) R01 Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis 1/7/2028 PAR-25-446 Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) UG3/UH3 Therapeutics Development 8/21/2028 PA-26-001 Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) UG3/UH3 Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis 11/30/2028 FOR-NS-25-002 Forecast for HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional), UG3/UH3 Therapeutics Development FORECASTED RFA-NS-25-031 HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) UG3/UH3 Therapeutics Development, Implementation & Health Services FORECASTED RFA-TR-26-002 Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Network (ERN) (Clinical Trial Not Allowed) ERN Therapeutics Development, Implementation & Health Services FORECASTED FOR-DA-26-001 HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional) R61/R33 Prevention, Recovery Services, Implementation & Health Services FORECASTED FOR-DA-27-001 HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems IMPOWR Implementation & Health Services FORECASTED RFA-DA-27-006 HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center IMPOWR/BEACON Implementation & Health Services FORECASTED FOR-DA-26-002 Limited Competition for the HEAL Initiative: HEALthy Brain and Child Development (HBCD) Study (Collaborative U01- Clinical Trial Not Allowed) U01 Life Course & Population FORECASTED FOR-DA-26-003 Limited Competition for the HEAL Initiative: HEALthy Brain and Child Development (HBCD) Study – Coordinating Administrative Core and Data Coordinating Center (U24 Clinical Trial Not Allowed) U24 Life Course & Population FORECASTED RFA-AR-26-006 Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0 RE-JOIN Preclinical FORECASTED RFA-NS-26-013 HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network PRECISION Preclinical FORECASTED This page last reviewed on February 25, 2026 www.nih.gov An official website of the Department of Health and Human Services Looking for U.S. government information and services? 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